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1) "Tricyclic" -- As to tricyclic antidepressant tri·cy·clic
Pronunciation: (")trI-'sI-klik, -'si-klik
Function: adjective
Etymology: tri- + cyclic
: being a chemical with three usually fused rings in the molecular structure and especially a tricyclic antidepressant Pronunciation Symbols
Chemical structure of the tricyclic antidepressant amitriptyline. Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. They are named after the drugs' molecular structure, which contains three rings of atoms (compare tetracyclic antidepressant). The term 'tricyclic antidepressant' is sometimes abbreviated to TCA. - 1 Mechanism of action
- 2 Clinical use
- 2.1 Depression
- 2.2 ADHD
- 2.3 Analgesia
- 2.4 Nocturnal enuresis
- 3 Side effects
- 4 Interactions
- 5 Overdose
- 5.1 Symptoms
- 5.2 Toxicity
- 5.3 Toxic mechanism
- 5.4 Treatment
- 5.5 Epidemiology
- 6 Example compounds
- 7 Footnotes
- 8 See also
| The exact mechanism of action is not well understood, however it is generally thought that tricylic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine, dopamine, or serotonin by nerve cells. Tricyclics may also possess an affinity for muscarinic and histamine H1 receptors to varying degrees. Although the pharmacologic effect occurs immediately, often the patient's symptoms do not respond for 2 to 4 weeks.[1] Tricyclic antidepressants are used in numerous applications; mainly indicated for the treatment of clinical depression, pain, nocturnal enuresis, and ADHD, but they have also been used successfully for headache, bulimia nervosa, interstitial cystitis, irritable bowel syndrome, narcolepsy, persistent hiccups, pathological crying or laughing, smoking cessation, as an adjunct in schizophrenia, and in ciguatera poisoning.
2) "Antidepressant" -- As to tricyclic antidepressant 1an·ti·de·pres·sant
Pronunciation: -di-'pre-s&nt
Function: adjective
: used or tending to relieve or prevent psychic depression Pronunciation Symbols
A recent form of antidepressant medication - Prozac Serotonin-norepinephrine reuptake inhibitor, Venlafaxine An antidepressant, in the most common usage, is a medication taken to alleviate clinical depression or dysthymia ('milder' depression). Several groups of drugs are particularly associated with the term, notably MAOIs and tricyclics (whose serendipitous discovery and psychiatric use dates from the 1950s) as well as SSRIs and more recent variations developed by pharmaceutical companies. These medications are now amongst the most commonly prescribed by psychiatrists and general practitioners, and their effectiveness and adverse effects are the subject of many studies and competing claims. A number of other antidepressant drugs, notably St John's Wort, are also widely studied and used. Antidepressants are generally, if not in pharmacology, considered separately from stimulants. They are usually taken as a course over several weeks, months or years, and have a delayed onset of therapeutic action. Drugs used for an immediate euphoric effect only are not generally considered antidepressants. Despite the name, antidepressants are often used in the treatment of other conditions, including anxiety disorders, bipolar disorder, eating disorders and chronic pain. Some have also become known as lifestyle drugs, sometimes referred to as "mood brighteners". Conversely other medications not known as antidepressants, including antipsychotics in low doses[1] and benzodiazepines[2] are also widely used to manage depression. In fact the antidepressant term is sometimes applied to any therapy (e.g. psychotherapy, electro-convulsive therapy, acupuncture) or process (e.g. sleep disruption, increased light levels, regular exercise) found to improve clinically depressed mood. It is also the case that placebos tend to have a significant antidepressant effect, so that establishing something as an antidepressant in a clinical trial involves demonstrating a significant additional effect.
Further Data On Term for tricyclic antidepressant
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Regularly Occuring Typos with tricyclic antidepressant include: rticyclic tircyclic trciyclic triycclic triccylic tricylcic tricycilc tricyclci ricyclic ticyclic trcyclic triyclic tricclic tricylic tricycic tricyclc tricycli rricyclic fricyclic gricyclic yricyclic teicyclic tdicyclic tficyclic tticyclic trucyclic trkcyclic trocyclic tracyclic trecyclic trucyclic trixyclic tridyclic trifyclic trivyclic trikyclic trictclic trichclic tricuclic tricyxlic tricydlic tricyflic tricyvlic tricyklic tricyckic tricycoic tricycpic tricycluc tricyclkc tricycloc tricyclac tricyclec tricycluc tricyclix tricyclid tricyclif tricycliv tricyclik natidepressant atnidepressant anitdepressant antdiepressant antiedpressant antidperessant antiderpessant antideperssant antideprsesant antidepressant antidepresasnt antidepressnat antidepressatn ntidepressant atidepressant anidepressant antdepressant antiepressant antidpressant antideressant antidepessant antideprssant antidepresant antidepresant antidepressnt antidepressat antidepressan qntidepressant sntidepressant zntidepressant entidepressant intidepressant ontidepressant untidepressant abtidepressant ahtidepressant ajtidepressant amtidepressant anridepressant anfidepressant angidepressant anyidepressant antudepressant antkdepressant antodepressant antadepressant antedepressant antudepressant antisepressant antixepressant anticepressant antifepressant antieepressant antitepressant antidwpressant antidspressant antiddpressant antidrpressant antidapressant antidipressant antidopressant antidupressant antideoressant antidepeessant antidepdessant antidepfessant antideptessant antideprwssant antideprsssant antideprdssant antideprrssant antideprassant antideprissant antideprossant antideprussant antidepreasant antideprewsant antidepredsant antideprexsant antideprezsant antidepresaant antidepreswant antidepresdant antidepresxant antidepreszant antidepressqnt antidepresssnt antidepressznt antidepressent antidepressint antidepressont antidepressunt antidepressabt antidepressaht antidepressajt antidepressamt antidepressanr antidepressanf antidepressang antidepressany
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